Article
Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes - 1 Sept 1995
Veijola R, Vähäsalo P, Tuomilehto-Wolf E, Reijonen H, Kulmala P, Ilonen J, Akerblom H K, Knip M
Abstract excerpt
To investigate the relationship between human leukocyte antigen (HLA)-associated genetic factors and the development of beta-cell dysfunction, we performed sequential intravenous glucose tolerance tests (IVGTTs) on 81 islet cell antibody (ICA)-positive and/or insulin autoantibody-positive healthy siblings of children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). A lower glucose disappearance...
Topics
- Adolescent
- Alleles
- Autoantibodies
- Blood Glucose
- Child
- Diabetes Mellitus, Type 1
- Female
- Follow-Up Studies
- Genotype
- Glucose Tolerance Test