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Article

Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.

Journal of cell science - 1 Aug 2014

Vagin Olga, Tokhtaeva Elmira, Garay Patton E, Souda Puneet, Bassilian Sara, Whitelegge Julian P, Lewis Ramilla, Sachs George, Wheeler Larry, Aoki Roger, Fernandez-Salas Ester

Abstract excerpt

Proteolytic cleavage of synaptosomal-associated protein 25 by the light chain of botulinum neurotoxin type A (LCA) results in a blockade of neurotransmitter release that persists for several months in motor neurons. The L428A/L429A mutation in LCA is known to significantly shorten both the proteo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24928902
DOI: 10.1242/jcs.146324
PMCID: PMC6518159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24928902-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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