Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.

Abstract excerpt

Proteolytic cleavage of synaptosomal-associated protein 25 by the light chain of botulinum neurotoxin type A (LCA) results in a blockade of neurotransmitter release that persists for several months in motor neurons. The L428A/L429A mutation in LCA is known to significantly shorten both the proteolytic and neuroparalytic effects of the neurotoxin in mice. To elucidate the cellular mechanism for LCA longevity, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurotoxicity Syndromes
• Share to Phenylurea Compounds