Article
p53 mutations in Barrett's adenocarcinoma and high-grade dysplasia.
Gastroenterology - 1 Jun 1994
Neshat K, Sanchez C A, Galipeau P C, Blount P L, Levine D S, Joslyn G, Reid B J
Abstract excerpt
BACKGROUND/AIMS: Allelic losses of chromosome 17p and overexpression of p53 protein have been reported in Barrett's adenocarcinomas. This study aimed to determine the stage in which p53 mutations arise in neoplastic progression in Barrett's esophagus and their relationship to the clonal evolution of cancer. METHODS: Fourteen patients with high-grade dysplasia, adenocarcinoma, or both arising in Barrett's...
Topics
- Adenocarcinoma
- Alleles
- Barrett Esophagus
- Base Sequence
- DNA Mutational Analysis
- Esophagus
- Humans
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Ploidies
- Polymerase Chain Reaction