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Article

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 1996

Galipeau P C, Cowan D S, Sanchez C A, Barrett M T, Emond M J, Levine D S, Rabinovitch P S, Reid B J

Abstract excerpt

Increased 4N (G2/tetraploid) cell populations have been postulated to be genetically unstable intermediates in the progression to many cancers, but the mechanism by which they develop and their relationship to instability have been difficult to investigate in humans in vivo. Barrett's esophagus is an excellent model system in which to investigate the order in which genetic and cell cycle abnormalities develop...

Topics

Alleles
Aneuploidy
Barrett Esophagus
Biopsy
Cell Cycle
Cell Transformation, Neoplastic
Chromosomes, Human, Pair 17
Flow Cytometry
Follow-Up Studies
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Humans

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Polyploidy

Source

Open in PubMed Open full text

Identifiers

PMID: 8692948
DOI: 10.1073/pnas.93.14.7081
PMCID: PMC38939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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