Article
17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma.
Cancer research - 15 Oct 1991
Blount P L, Ramel S, Raskind W H, Haggitt R C, Sanchez C A, Dean P J, Rabinovitch P S, Reid B J
Abstract excerpt
Barrett's esophagus is a condition in which the stratified squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium that predisposes to the development of esophageal adenocarcinoma. Allelic deletions of 17p and alterations of p53 including elevated p53 protein levels have been observed in many different tumors. To investigate the presence of 17p allelic deletions and p53 protein...
Topics
- Adenocarcinoma
- Alleles
- Aneuploidy
- Barrett Esophagus
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Esophageal Neoplasms
- Humans
- Polymorphism, Restriction Fragment Length
- Tumor Suppressor Protein p53