Article
Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2008
Chao Dennis L, Sanchez Carissa A, Galipeau Patricia C, Blount Patricia L, Paulson Thomas G, Cowan David S, Ayub Kamran, Odze Robert D, Rabinovitch Peter S, Reid Brian J
Abstract excerpt
PURPOSE: Elevated cellular proliferation and cell cycle abnormalities, which have been associated with premalignant lesions, may be caused by inactivation of tumor suppressor genes. We measured proliferative and cell cycle fractions of biopsies from a cohort of patients with Barrett's esophagus to better understand the role of proliferation in early neoplastic progression and the association between cell cycle...
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