Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.

Article

Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.

Leukemia - 1 Jan 1992

Longmore G D, Pharr P, Lodish H F

Abstract excerpt

Erythropoietin (Epo) is the major regulator of erythroid viability, proliferation, and differentiation. These functions are transduced following binding of Epo to a specific cell surface receptor, the erythropoietin receptor (EpoR), a member of a new cytokine receptor superfamily of receptors. An...

Topics

3T3 Cells
Animals
Erythrocytes
Erythroid Precursor Cells
Erythropoietin
Mice
Mice, Inbred BALB C
Mutation
Polycythemia Vera
Receptors, Cell Surface
Receptors, Erythropoietin
Splenomegaly

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