Article
Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus.
Journal of virology - 1 Jun 1994
Portis J L, Spangrude G J, McAtee F J
Abstract excerpt
Neonatal inoculation of the wild-mouse ecotropic retrovirus CasBrE (clone 15-1) causes a noninflammatory spongiform neurodegenerative disease with an incubation period of > or = 6 months. Introduction of sequences from Friend murine leukemia virus (clone FB29) into the genome of CasBrE results in...
Topics
- Amino Acid Sequence
- Animals
- Animals, Newborn
- Base Sequence
- Central Nervous System Diseases
- DNA, Viral
- Gene Products, gag
- Genes, gag
- Glycosylation
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Open Reading Frames
- Phenotype
- Point Mutation
- Retroviridae
- Retroviridae Infections
- Time Factors