Article
Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex.
Journal of virology - 1 Oct 2003
Planz Oliver, Pleschka Stephan, Oesterle Katja, Berberich-Siebelt Friederike, Ehrhardt Christina, Stitz Lothar, Ludwig Stephan
Abstract excerpt
Transition from G(2) to M phase, a cell cycle checkpoint, is regulated by the Cdc2-cyclin B1 complex. Here, we report that persistent infection with Borna disease virus (BDV), a noncytolytic RNA virus infecting the central nervous system, results in decelerated proliferation of infected host cells due to a delayed G(2)-to-M transition. Persistent BDV-infected rat fibroblast cells showed reduced proliferation...
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