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Article

Characterization of an In Vitro Model of Alphavirus Infection of Immature and Mature Neurons

24 Feb 2005

Abstract excerpt

Terminally differentiated, mature neurons are essential cells that are not easily regenerated. Neurotropic viruses, such as Sindbis virus (SV), cause encephalomyelitis through their ability to replicate in neurons. SV causes the death of immature neurons, while mature neurons can often survive infection. The lack of a reproducible and convenient neuronal cell culture system has hindered a detailed study of the...

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PMID: 15731238
DOI: 10.1128/jvi.79.6.3438-3447.2005

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