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Article

Attenuation of Semliki Forest Virus Neurovirulence by MicroRNA-Mediated Detargeting

18 Oct 2012

Abstract excerpt

Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. Semliki Forest virus (SFV) is a positive-strand RNA virus and, similar to the related...

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PMID: 23077310
DOI: 10.1128/jvi.01940-12

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