A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.

Article

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.

The EMBO journal - 2 Sept 1996

Mohr I, Gluzman Y

Abstract excerpt

Novel suppressor variants of conditionally lethal HSV-1 gamma34.5 deletion mutants have been isolated which exhibit restored ability to grow on neoplastic neuronal cells. Deletion of the viral gamma34.5 genes, whose products share functional similarity with the cellular GADD34 gene, renders the v...

Topics

Enzyme Activation
Genes, Suppressor
Genetic Markers
Herpesvirus 1, Human
Mutation
Protein Biosynthesis
Protein Serine-Threonine Kinases
Proteins
Tumor Cells, Cultured
eIF-2 Kinase

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