Article
The R-U5-5' leader sequence of neurovirulent wild mouse retrovirus contains an element controlling the incubation period of neurodegenerative disease.
Journal of virology - 1 Apr 1991
Portis J L, Perryman S, McAtee F J
Abstract excerpt
The wild mouse ecotropic retrovirus CasBrE causes a spongiform neurodegenerative disease after neonatal inoculation, with an incubation period ranging from 2 to 12 months. We previously showed that introduction of long terminal repeat (LTR) and gag-pol sequences from a strain of Friend murine leu...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System Diseases
- Chimera
- Consensus Sequence
- DNA, Viral
- Enhancer Elements, Genetic
- Mice
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals
- RNA Splicing
- RNA, Messenger
- Repetitive Sequences, Nucleic Acid
- Retroviridae
- Viral Envelope Proteins
- Viremia