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Article

The R-U5-5' leader sequence of neurovirulent wild mouse retrovirus contains an element controlling the incubation period of neurodegenerative disease.

Journal of virology - 1 Apr 1991

Portis J L, Perryman S, McAtee F J

Abstract excerpt

The wild mouse ecotropic retrovirus CasBrE causes a spongiform neurodegenerative disease after neonatal inoculation, with an incubation period ranging from 2 to 12 months. We previously showed that introduction of long terminal repeat (LTR) and gag-pol sequences from a strain of Friend murine leukemia virus (FB29) resulted in a dramatic acceleration of the onset of the disease. The chimeric virus FrCasE, which...

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Identifiers

PMID: 2002548
DOI: 10.1128/JVI.65.4.1877-1883.1991
PMCID: PMC239999

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