Article
The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein.
Virology - 15 Dec 1996
Portis J L, Fujisawa R, Mcatee F J
Abstract excerpt
Neuroinvasiveness is a property of all neurovirulent murine retroviruses, although the factors which facilitate infection of the CNS are not understood. We previously showed that mutant MuLV which lack expression of an accessory protein, glycosylated gag, had lost neurovirulence, indicating that...
Topics
- Amino Acid Sequence
- Animals
- Animals, Newborn
- DNA, Viral
- Gene Products, gag
- Glycosylation
- Immunoblotting
- Leukemia Virus, Murine
- Mice
- Molecular Sequence Data
- Mutagenesis
- Nervous System Diseases
- Phenotype
- Recombination, Genetic
- Retroviridae Infections
- Spleen
- Tumor Virus Infections
- Virulence