Brain infection by neuroinvasive but avirulent murine oncornaviruses.

doi:10.1128/jvi.74.1.465-473.2000

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Article

Brain infection by neuroinvasive but avirulent murine oncornaviruses.

Journal of virology - 1 Jan 2000

Asković S, McAtee F J, Favara C, Portis J L

Abstract excerpt

The chimeric murine oncornavirus FrCas(E) causes a rapidly progressive noninflammatory spongiform encephalomyelopathy after neonatal inoculation. The virus was constructed by the introduction of pol-env sequences from the wild mouse virus CasBrE into the genome of a neuroinvasive but nonneurovirulent strain of Friend murine leukemia virus (FMuLV), FB29. Although the brain infection by FrCas(E) as well as that by...

Topics

Animals
Astrocytes
Encephalitis, Viral
Mice
Mice, Inbred Strains
Microglia
Phenotype
Retroviridae
Retroviridae Infections
Virulence

Source

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Identifiers

PMID: 10590136
DOI: 10.1128/jvi.74.1.465-473.2000
PMCID: PMC111558

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