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Article

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

Oncogene - 1 Jun 1994

Bristow R G, Jang A, Peacock J, Chung S, Benchimol S, Hill R P

Abstract excerpt

Recently, it has been suggested that abrogation of the wild type p53 protein function may alter the cellular response to DNA damaging agents, including ionizing radiation. This study was designed to compre the relative radiosensitivity and tumorigenicity of rat embryo fibroblast (REF) cell lines...

Topics

Animals
Cell Survival
Fibroblasts
Genes, p53
Genes, ras
Mice
Mice, Nude
Mutation
Neoplasms, Experimental
Oncogene Proteins, Viral
Papillomavirus E7 Proteins
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiation Tolerance

Rats

Rats, Inbred F344

Transfection

Source

Identifiers

PMID: 8183546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8183546-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.PMID 8183546Read ↗

P53-mediated radioresistance does not correlate with metastatic potential in tumorigenic rat embryo cell lines following oncogene transfection.Semantic proximity Read ↗

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation.Semantic proximity Read ↗

Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53.Semantic proximity Read ↗

Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2.Semantic proximity Read ↗

Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance.Semantic proximity Read ↗

Rat primary embryo fibroblast cells suppress transformation by the E6 and E7 genes of human papillomavirus type 16 in somatic hybrid cells.Semantic proximity Read ↗

Synergism between pairs of immortalizing genes in transformation assays of rat embryo fibroblasts.Semantic proximity Read ↗

A transcript exhibiting homology to endogenous rat retroviral-like elements is regulated by p53.Semantic proximity Read ↗

Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF).Semantic proximity Read ↗

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.Semantic proximity Read ↗

Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy.Semantic proximity Read ↗

Stability of p53 protein in rat cells transformed by various viral transforming genes.Semantic proximity Read ↗

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