Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy.

doi:10.1007/BF01053280

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Article

Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy.

Journal of neuro-oncology - 1 Jan 1994

Asai A, Miyagi Y, Sugiyama A, Gamanuma M, Hong S H, Takamoto S, Nomura K, Matsutani M, Takakura K, Kuchino Y

Abstract excerpt

Human (U251, U87, U343) and rat glioma cell lines (C6, 9L) were examined by the reverse transcriptase-polymerase chain reaction and subsequent nucleotide sequencing analysis to see whether they express wild type (wt)-p53 or mutated form (mut)-p53 messages. Results showed that U87, U343, and C6 ce...

Topics

Animals
Base Sequence
Brain Neoplasms
Cell Cycle
Gene Amplification
Gene Expression
Genes, myc
Genes, p53
Glioma
Humans
Molecular Sequence Data
Phenotype
Point Mutation
Polymerase Chain Reaction
Proto-Oncogene Proteins c-myc

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Open in PubMed

Identifiers

PMID: 7807177
DOI: 10.1007/BF01053280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7807177-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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