Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation.

doi:10.1038/sj.onc.1201935

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Article

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation.

Oncogene - 9 Apr 1998

Bristow R G, Hu Q, Jang A, Chung S, Peacock J, Benchimol S, Hill R

Abstract excerpt

Recent data suggest that aberrant function of the wild type p53 protein (WTp53) may alter cellular survival following DNA damage through cellular pathways involving apoptosis and cell-cycle checkpoints, but little is known concerning it's possible role in DNA repair. In the present study, the ionizing radiation sensitivity was determined for a series of rat embryo fibroblast (REF) cell lines transfected with an...

Topics

Animals
Apoptosis
Cell Line, Transformed
Clone Cells
DNA
DNA Damage
DNA Repair
Dose-Response Relationship, Radiation
Embryo, Mammalian
Fibroblasts
G1 Phase
Gamma Rays
Humans
Mice
Mutation
Radiation Tolerance
Rats
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9583677
DOI: 10.1038/sj.onc.1201935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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