Article
P53-mediated radioresistance does not correlate with metastatic potential in tumorigenic rat embryo cell lines following oncogene transfection.
International journal of radiation oncology, biology, physics - 15 Jan 1996
Bristow R G, Brail L, Jang A, Peacock J, Chung S, Benchimol S, Hill R P
Abstract excerpt
PURPOSE: Changes in wild-type p53 protein function occur in the majority of human tumors, and may alter genomic stability and the cellular response to ionizing radiation. Whether oncoproteins can render tumor cells both radioresistant and metastatic, may have implications for clinical strategies...
Topics
- Animals
- Blotting, Western
- Cell Line, Transformed
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Embryo, Mammalian
- Genes, Viral
- Genes, p53
- Genes, ras
- Genetic Vectors
- Genotype
- Humans
- Immunocompromised Host
- Mice
- Mice, SCID
- Mutation
- Neoplasm Metastasis
- Papillomaviridae