Article
Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance.
Radiation research - 1 Nov 1994
Pardo F S, Su M, Borek C, Preffer F, Dombkowski D, Gerweck L, Schmidt E V
Abstract excerpt
Dominant oncogenic sequences have been shown to modulate the intrinsic radiation sensitivity of cells of both human and murine tumor cell lines. Whether transfection with candidate tumor-suppressor genes can modulate intrinsic radiation sensitivity is unknown. The data presented here demonstrate that transfection of rat embryo cells with a mutant p53 allele can increase the intrinsic radiation resistance of cells...
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