Article
Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance.
Radiation research - 1 Nov 1994
Pardo F S, Su M, Borek C, Preffer F, Dombkowski D, Gerweck L, Schmidt E V
Abstract excerpt
Dominant oncogenic sequences have been shown to modulate the intrinsic radiation sensitivity of cells of both human and murine tumor cell lines. Whether transfection with candidate tumor-suppressor genes can modulate intrinsic radiation sensitivity is unknown. The data presented here demonstrate...
Topics
- Animals
- Cell Cycle
- Cells, Cultured
- Embryo, Mammalian
- Genes, p53
- Mutation
- Radiation Tolerance
- Rats
- Rats, Sprague-Dawley
- Transfection