Article
Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila.
Developmental biology - 1 Nov 1995
Agrawal N, Kango M, Mishra A, Sinha P
Abstract excerpt
Homozygosity for lethal(2)giant larvae (lgl), a mutation in a tumor suppressor gene of Drosophila, induces neoplasia of the imaginal discs. To explore the developmental capacities of lgl mutant cells, we have investigated their growth and differentiation in genetic mosaics. Adult wings mosaic for...
Topics
- Animals
- Cell Communication
- Cell Differentiation
- Cell Transformation, Neoplastic
- Drosophila
- Drosophila Proteins
- Female
- Genes, Insect
- Genes, Tumor Suppressor
- Genotype
- Insect Hormones
- Larva
- Male
- Mitosis
- Mosaicism
- Mutation
- Recombination, Genetic
- Tumor Suppressor Proteins