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Article

A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2010

Menéndez Javier, Pérez-Garijo Ainhoa, Calleja Manuel, Morata Ginés

Abstract excerpt

Mutant larvae for the Drosophila gene lethal giant larva (lgl) develop neoplastic tumors in imaginal discs. However, lgl mutant clones do not form tumors when surrounded by wild-type tissue, suggesting the existence of a tumor-suppressing mechanism. We have investigated the tumorigenic potential of lgl mutant cells by generating wing compartments that are entirely mutant for lgl and also inducing clones of...

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Identifiers

PMID: 20679206
DOI: 10.1073/pnas.1009376107
PMCID: PMC2930466

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