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Article

Metastatic ability of Drosophila tumors depends on MMP activity.

Developmental biology - 15 Mar 2007

Beaucher Michelle, Hersperger Evelyn, Page-McCaw Andrea, Shearn Allen

Abstract excerpt

We analyzed how cells from tumors caused by mutations in either lgl or brat use matrix metalloproteinases (MMPs) to facilitate metastasis in Drosophila. MMP1 accumulation is dramatically increased in lgl larval imaginal discs compared to both wild type and brat mutants. Removal of Mmp1 gene activity in lgl brain tumor cells reduced their frequency of ovarian micro-metastases after transplantation; whereas,...

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Source

Identifiers

PMID: 17239363
DOI: 10.1016/j.ydbio.2006.12.001

Genes

MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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