Article
No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
Science (New York, N.Y.) - 26 Apr 2002
Levinson Douglas F, Holmans Peter A, Laurent Claudine, Riley Brien, Pulver Ann E, Gejman Pablo V, Schwab Sibylle G, Williams Nigel M, Owen Michael J, Wildenauer Dieter B, Sanders Alan R, Nestadt Gerald, Mowry Bryan J, Wormley Brandon, Bauché Stephanie, Soubigou Stephane, Ribble Robert, Nertney Deborah A, Liang Kung Yee, Martinolich Laura, Maier Wolfgang, Norton Nadine, Williams Hywel, Albus Margot, Carpenter Eric B, DeMarchi Nicola, Ewen-White Kelly R, Walsh Dermot, Jay Maurice, Deleuze Jean-François, O'Neill F Anthony, Papadimitriou George, Weilbaecher Ann, Lerer Bernard, O'Donovan Michael C, Dikeos Dimitris, Silverman Jeremy M, Kendler Kenneth S, Mallet Jacques, Crowe Raymond R, Walters Marilyn
Abstract excerpt
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin...
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