Article
Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy.
The New England journal of medicine - 9 Jun 1994
Schunkert H, Hense H W, Holmer S R, Stender M, Perz S, Keil U, Lorell B H, Riegger G A
Abstract excerpt
BACKGROUND: Epidemiologic studies have shown that left ventricular hypertrophy is often found in the absence of an elevated cardiac workload. To investigate whether such hypertrophy is determined in part by genetic factors, we studied the association between this condition, as assessed by electrocardiographic criteria, and a deletion (D)-insertion (I) polymorphism of the angiotensin-converting-enzyme (ACE) gene....
Topics
- Aged
- Alleles
- Confidence Intervals
- Cross-Sectional Studies
- Electrocardiography
- Female
- Gene Deletion
- Humans
- Hypertrophy, Left Ventricular
- Male
- Middle Aged