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Article

Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism.

Circulation - 15 Sept 1995

Danser A H, Schalekamp M A, Bax W A, van den Brink A M, Saxena P R, Riegger G A, Schunkert H

Abstract excerpt

BACKGROUND: An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with differences in the plasma levels of ACE as well as with myocardial infarction, cardiomyopathy, left ventricular hypertrophy, and coronary artery disease. METHODS AND RESULTS: We determined the cardiac ACE activity and the ACE genotype in 71 subjects who died of noncardiac disorders....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7664416
DOI: 10.1161/01.cir.92.6.1387

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism.PMID 7664416Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.Semantic proximity Read ↗

Angiotensin I-converting enzyme insertion/deletion polymorphism: clinical implications.Semantic proximity Read ↗

Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis.Semantic proximity Read ↗

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis.Semantic proximity Read ↗

[ACE gene polymorphism and cardiovascular diseases].Semantic proximity Read ↗

Angiotensin-converting enzyme polymorphism in healthy young subjects: relationship to left ventricular mass and functions.Semantic proximity Read ↗

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.Semantic proximity Read ↗

DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy.Semantic proximity Read ↗

Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction.Semantic proximity Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.Semantic proximity Read ↗

Deletion polymorphism of angiotensin-converting enzyme gene and left ventricular hypertrophy in southern Italian patients.Semantic proximity Read ↗

A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction.Semantic proximity Read ↗

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