Article
Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.
European heart journal - 1 Dec 2004
Schut Anna F C, Bleumink Gysèle S, Stricker Bruno H Ch, Hofman Albert, Witteman Jacqueline C M, Pols Huibert A P, Deckers Jaap W, Deinum Jaap, van Duijn Cornelia M
Abstract excerpt
AIMS: Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. METHODS AND RESULTS: We...
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