Article
Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass.
The New England journal of medicine - 18 Apr 1996
Lindpaintner K, Lee M, Larson M G, Rao V S, Pfeffer M A, Ordovas J M, Schaefer E J, Wilson A F, Wilson P W, Vasan R S, Myers R H, Levy D
Abstract excerpt
BACKGROUND: Homozygous carries of the D allele of the angiotensin-converting-enzyme (ACE) gene have been reported to be at increased risk for various cardiovascular disorders, including left ventricular hypertrophy. We investigated the potential role of the ACE gene in influencing left ventricular mass. METHODS: Quantitative echocardiographic data and DNA samples were available for 2439 subjects from the...
Topics
- Adult
- Algorithms
- Base Sequence
- Female
- Gene Frequency
- Genetic Linkage
- Genotype
- Growth Hormone
- Heart Ventricles
- Humans
- Hypertrophy, Left Ventricular
- Linear Models
- Male
- Middle Aged