Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis.

doi:10.1038/sj.jhh.1001055

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Article

Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis.

Journal of human hypertension - 1 Jul 2000

Kuznetsova T, Staessen J A, Wang J G, Gasowski J, Nikitin Y, Ryabikov A, Fagard R

Abstract excerpt

This meta-analysis attempted to derive pooled estimates for the putative association between echocardiographic or electrocardiographic left ventricular hypertrophy and the deletion/insertion (D/I) polymorphism of the angiotensin-I converting enzyme. Case-control studies were combined, using the Mantel and Haenszel approach. Joint P-values for continuous variables were calculated by Stouffer's method. Continuous...

Topics

Alleles
Antihypertensive Agents
Case-Control Studies
Genotype
Humans
Hypertension
Hypertrophy, Left Ventricular
Peptidyl-Dipeptidase A
Polymorphism, Genetic

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Open in PubMed

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PMID: 10918550
DOI: 10.1038/sj.jhh.1001055

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