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Article

DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy.

Circulation - 1 Dec 1994

Iwai N, Ohmichi N, Nakamura Y, Kinoshita M

Abstract excerpt

BACKGROUND: The cardiac renin-angiotensin system has been suggested to be involved in the development of left ventricular hypertrophy. In humans, a strong correlation has been found between plasma angiotensin I-converting enzyme (ACE) activity and the insertion/deletion (I/D) polymorphism of the ACE gene, which has been reported to be associated with myocardial infarction, ischemic and idiopathic dilated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7994801
DOI: 10.1161/01.cir.90.6.2622

Genes

ACE
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy.PMID 7994801Read ↗

Deletion polymorphism of angiotensin-converting enzyme gene and left ventricular hypertrophy in southern Italian patients.Semantic proximity Read ↗

Angiotensin-converting enzyme polymorphism in healthy young subjects: relationship to left ventricular mass and functions.Semantic proximity Read ↗

Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis.Semantic proximity Read ↗

Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Usefulness of the I/D angiotensin-converting enzyme genotype for detecting the risk of left ventricular hypertrophy in pharmacologically treated hypertensive men.Semantic proximity Read ↗

Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk: A systematic review and meta-analysis.Semantic proximity Read ↗

[I/D gene polymorphism of the angiotensin-converting enzyme and left ventricular hypertrophy. Response to converting enzyme inhibitors].Semantic proximity Read ↗

Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension.Semantic proximity Read ↗

Hypertensive left ventricular remodeling and ACE-gene polymorphism.Semantic proximity Read ↗

ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy.Semantic proximity Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism and geometric patterns of hypertensive left ventricular hypertrophy.Semantic proximity Read ↗

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