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Article

DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy.

Circulation - 1 Dec 1994

Iwai N, Ohmichi N, Nakamura Y, Kinoshita M

Abstract excerpt

BACKGROUND: The cardiac renin-angiotensin system has been suggested to be involved in the development of left ventricular hypertrophy. In humans, a strong correlation has been found between plasma angiotensin I-converting enzyme (ACE) activity and the insertion/deletion (I/D) polymorphism of the...

Topics

Adult
Aged
Alleles
Base Sequence
Blood Pressure
Echocardiography
Gene Deletion
Genotype
Heart Ventricles
Humans
Hypertrophy, Left Ventricular
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Peptidyl-Dipeptidase A

Polymorphism, Genetic

Risk Factors

Source

Identifiers

PMID: 7994801
DOI: 10.1161/01.cir.90.6.2622

Genes

ACE
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7994801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy.PMID 7994801Read ↗

Deletion polymorphism of angiotensin-converting enzyme gene and left ventricular hypertrophy in southern Italian patients.Semantic proximity Read ↗

Angiotensin-converting enzyme polymorphism in healthy young subjects: relationship to left ventricular mass and functions.Semantic proximity Read ↗

Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis.Semantic proximity Read ↗

Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Usefulness of the I/D angiotensin-converting enzyme genotype for detecting the risk of left ventricular hypertrophy in pharmacologically treated hypertensive men.Semantic proximity Read ↗

Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk: A systematic review and meta-analysis.Semantic proximity Read ↗

[I/D gene polymorphism of the angiotensin-converting enzyme and left ventricular hypertrophy. Response to converting enzyme inhibitors].Semantic proximity Read ↗

Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension.Semantic proximity Read ↗

Hypertensive left ventricular remodeling and ACE-gene polymorphism.Semantic proximity Read ↗

ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy.Semantic proximity Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism and geometric patterns of hypertensive left ventricular hypertrophy.Semantic proximity Read ↗

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