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Article

Insulin like growth factor-I independence in rat mammary carcinoma cells: a dominant phenotype in somatic cell hybrid experiments.

Cancer letters - 1 Nov 1993

Ethier S P, Taback E

Abstract excerpt

Normal rat mammary epithelial cells have an absolute requirement for insulin (IN) or insulin-like growth factor-I (IGF-I) for proliferation in serum-free medium. By contrast, serially transplantable rat mammary carcinoma (RMC) cells are IGF-I-independent for continuous growth in vitro. Previously, we demonstrated that IGF-I independence is not mediated by an autocrine loop. Therefore, experiments were carried out...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8174103
DOI: 10.1016/0304-3835(93)90242-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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