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Article

Insulin like growth factor-I independence in rat mammary carcinoma cells: a dominant phenotype in somatic cell hybrid experiments.

Cancer letters - 1 Nov 1993

Ethier S P, Taback E

Abstract excerpt

Normal rat mammary epithelial cells have an absolute requirement for insulin (IN) or insulin-like growth factor-I (IGF-I) for proliferation in serum-free medium. By contrast, serially transplantable rat mammary carcinoma (RMC) cells are IGF-I-independent for continuous growth in vitro. Previously...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Breast Neoplasms
Cell Division
Humans
Hybrid Cells
Insulin
Insulin-Like Growth Factor I
Mammary Neoplasms, Experimental
Phenotype
Rats
Tumor Cells, Cultured

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Identifiers

PMID: 8174103
DOI: 10.1016/0304-3835(93)90242-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8174103-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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