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Article

Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor.

The Journal of biological chemistry - 28 Feb 2003

Yu Dong, Watanabe Hiroshi, Shibuya Hitoshi, Miura Masahiko

Abstract excerpt

The insulin-like growth factor I receptor (IGF-IR) has the ability to confer clonogenic radioresistance following ionizing irradiation. We attempted to determine the downstream pathways involved in IGF-IR-mediated radioresistance and used mouse embryo fibroblasts deficient in endogenous IGF-IR (R-) as recipients for a number of mutant IGF-IRs. Mutational analysis revealed that the tyrosine at residue 950...

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Source

Identifiers

PMID: 12493743
DOI: 10.1074/jbc.M209809200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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