Article
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Science (New York, N.Y.) - 29 Apr 1994
Vitaterna M H, King D P, Chang A M, Kornhauser J M, Lowrey P L, McDonald J D, Dove W F, Pinto L H, Turek F W, Takahashi J S
Abstract excerpt
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human...
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