Article
Mutagenesis and behavioral screening for altered circadian activity identifies the mouse mutant, Wheels.
Brain research - 24 Dec 1995
Pickard G E, Sollars P J, Rinchik E M, Nolan P M, Bucan M
Abstract excerpt
The molecular processes underlying the generation of circadian behavior in mammals are virtually unknown. To identify genes that regulate or alter circadian activity rhythms, a mouse mutagenesis program was initiated in conjunction with behavioral screening for alterations in circadian period (tau), a fundamental property of the biological clock. Male mice of the inbred BALB/c strain, treated with the potent...
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