Forward genetic approaches to circadian clocks in mice.

Abstract excerpt

The study of mammalian circadian rhythms has a rich history of physiological understanding, but the molecular elements of the mammalian clock remain to be discovered. Availability of effective mutagenesis procedures and mouse molecular genetics resources sufficient for the task of positional cloning give cause for hope that the Clock gene, as well as other components of the mammalian circadian system, will be...

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