Article
Positional cloning of the mouse circadian clock gene.
Cell - 16 May 1997
King D P, Zhao Y, Sangoram A M, Wilsbacher L D, Tanaka M, Antoch M P, Steeves T D, Vitaterna M H, Kornhauser J M, Lowrey P L, Turek F W, Takahashi J S
Abstract excerpt
We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning approximately 100,000 bp of DNA from which transcript classes of 7.5 and approximately 10 kb arise. Clock encodes a novel member of the bHLH-PAS family of transcription factors. In the Clock mutant allele, an A-->T nucleotide transversion in a splice donor site causes exon skipping...
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