N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders.

Abstract excerpt

Twin and adoption studies have consistently implicated genetics in the aetiology of psychiatric and behavioural disorders. The identification of the genes and molecular pathways that are associated with these traits using linkage studies has been difficult because psychiatric disorders are almost always non-mendelian, heterogeneous, involve multiple genetic loci and are influenced significantly by environmental...

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