Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.

Carcinogenesis - 1 Dec 1991

Barch D H, Jacoby R F, Brasitus T A, Radosevich J A, Carney W P, Iannaccone P M

Abstract excerpt

Activation of the ras oncogene was investigated in esophageal tumors induced by methylbenzylnitrosamine (MBN) in the Sprague-Dawley rat. DNA was extracted from grossly visible carcinogen-induced tumors. H-ras and K-ras gene sequences were then amplified by the polymerase chain reaction. Point mutations in the ras genes were then identified by selective hybridization to allele-specific oligonucleotide probes. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Codon
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Immunohistochemistry

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 1747941
DOI: 10.1093/carcin/12.12.2373

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.PMID 1747941Read ↗

Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.Semantic proximity Read ↗

Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.Semantic proximity Read ↗

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.Semantic proximity Read ↗

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.Semantic proximity Read ↗

Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.Semantic proximity Read ↗

Mutation in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine.Semantic proximity Read ↗

Decreased tumorigenesis in mice with a Kras point mutation at C118.Semantic proximity Read ↗

H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.Semantic proximity Read ↗

Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.Semantic proximity Read ↗

Association between p53 immunostaining and cigarette smoking in squamous cell carcinoma of the esophagus.Semantic proximity Read ↗

K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.Semantic proximity Read ↗

High frequency of Ki-ras amplification and p53 gene mutations in adenocarcinomas of the human esophagus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.