Alterations in H-ras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy.

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Article

Alterations in H-ras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy.

Cancer research - 1 Nov 1996

Jin Z, Houle B, Mikheev A M, Cha R S, Zarbl H

Abstract excerpt

We previously demonstrated that H-ras1 oncogene mutations detected in N-nitroso-N-methylurea (NMU)-induced mammary tumors arose as background mutations within rat mammary cells (RMCs) and that NMU promoted the outgrowth of these preexisting mutants. We have now detected a putative DNA structure i...

Topics

Animals
Carcinogens
DNA Methylation
DNA, Neoplasm
Female
Genes, ras
Gonadal Steroid Hormones
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Nucleic Acid Conformation
Polymerase Chain Reaction
Pregnancy
Pregnancy, Animal
Promoter Regions, Genetic
Rats
Rats, Inbred F344

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Open in PubMed

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PMID: 8895746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8895746-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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