Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

doi:10.1038/306658a0

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Article

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

Nature - 1 Jan 2000

Sukumar S, Notario V, Martin-Zanca D, Barbacid M

Abstract excerpt

Each of nine mammary carcinomas induced by a single injection of nitroso-methylurea into 50-day-old Buf/N female rats, contained a transforming H-ras-1 gene. Molecular characterization of one of the genes revealed that the twelfth codon was GAA instead of GGA of the normal allele, encoding glutam...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
DNA Restriction Enzymes
Female
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Neoplasm Proteins
Nitrosourea Compounds
Oncogenes
Rats

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