Article
WT1, WTX and CTNNB1 mutation analysis in 43 patients with sporadic Wilms' tumor.
Oncology reports - 1 Jan 2013
Cardoso Leila C A, De Souza Kelly R L, De O Reis Adriana Helena, Andrade Raissa Coelho, Britto Alberto C, De Lima Maria A F D, Dos Santos Anna C E, De Faria Paulo S, Ferman Sima, Seuánez Héctor N, Vargas Fernando R
Abstract excerpt
Wilms' tumor (WT) is a heterogeneous neoplasia characterized by a number of genetic abnormalities, involving tumor suppressor genes, oncogenes and genes related to the Wnt signaling pathway. Somatic biallelic inactivation of WT1 is observed in 5-10% of sporadic WT. Somatic mutations in exon 3 of CTNNB1, which encodes β-catenin, were initially observed in 15% of WT....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.