Article
Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.
The Journal of infectious diseases - 1 May 1994
Altamirano M, Marostenmaki J, Wong A, FitzGerald M, Black W A, Smith J A
Abstract excerpt
Isoniazid resistance in Mycobacterium tuberculosis has been associated with total deletion of the katG gene, which codes for catalase-peroxidase production. To determine whether this is a common mechanism of drug resistance, 9 isolates of isoniazid-resistant and 1 of isoniazid-sensitive M. tuberc...
Topics
- Bacterial Proteins
- Base Sequence
- Catalase
- DNA, Bacterial
- Drug Resistance, Microbial
- Genes, Bacterial
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Peroxidases
- Polymerase Chain Reaction