Article
Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.
The Journal of infectious diseases - 1 Jan 1996
Musser J M, Kapur V, Williams D L, Kreiswirth B N, van Soolingen D, van Embden J D
Abstract excerpt
The catalase-peroxidase gene (katG) and a two-gene locus (inhA) containing mutations associated with resistance to isoniazid in Mycobacterium tuberculosis were sequenced in 34 resistant and 12 susceptible strains. Virtually all resistant organisms had amino acid changes in KatG or nucleotide subs...
Topics
- Amino Acid Sequence
- Antitubercular Agents
- Bacterial Proteins
- Base Sequence
- Catalase
- DNA, Bacterial
- Drug Resistance, Microbial
- Genes, Bacterial
- Humans
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis