Article
Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis.
Infection and immunity - 1 Apr 1995
Rouse D A, Morris S L
Abstract excerpt
Genetic and biochemical studies have suggested a link between reduced catalase activity and resistance to isoniazid in Mycobacterium tuberculosis. In this study, we examined the molecular mechanisms of resistance to isoniazid with six in vitro mutants of the M. tuberculosis complex (Mycobacterium bovis and M. tuberculosis). Five of six mutants resistant to isoniazid were negative by catalase assays. Immunoblot...
Topics
- Base Sequence
- Catalase
- DNA Primers
- DNA, Bacterial
- Drug Resistance, Microbial
- Genes, Bacterial
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium bovis
- Mycobacterium tuberculosis