Article
Characterization of isoniazid-resistant strains of Mycobacterium tuberculosis on the basis of phenotypic properties and mutations in katG.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 May 2001
Abate G, Hoffner S E, Thomsen V O, Miörner H
Abstract excerpt
Forty isoniazid-resistant Mycobacterium tuberculosis isolates were characterized on the basis of phenotypic properties (i.e., catalase activity, MIC of isoniazid, and growth pattern in the presence of 7 different concentrations of isoniazid) and alterations in the katG gene (codons 315 and 463). Three different growth patterns could be distinguished: concentration-dependent inhibition of growth was observed in 29...
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