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Article

Identification of <i>katG</i> Mutations Associated with High-Level Isoniazid Resistance in <i>Mycobacterium tuberculosis</i>

9 Mar 2010

Abstract excerpt

Isoniazid (INH) is an effective first-line antituberculosis drug. KatG, a catalase-peroxidase, converts INH to an active form in Mycobacterium tuberculosis, and katG mutations are major causes of INH resistance. In the present study, we sequenced katG of 108 INH-resistant M. tuberculosis clinical isolates. Consequently, 9 novel KatG mutants with a single-amino-acid substitution were found. All of these mutants...

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Identifiers

PMID: 20211896
DOI: 10.1128/aac.01691-09

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