Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.

doi:10.1128/AAC.47.2.670-675.2003

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Article

Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.

Antimicrobial agents and chemotherapy - 1 Feb 2003

Wei Chih-Jen, Lei Benfang, Musser James M, Tu Shiao-Chun

Abstract excerpt

Mycobacterium tuberculosis KatG catalyzes the activation of the antitubercular agent isoniazid to yield an inhibitor targeting enoyl reductase (InhA). However, no firm biochemical link between many KatG variants and isoniazid resistance has been established. In the present study, six distinct KatG variants identified in clinical Mycobacterium tuberculosis isolates resistant to isoniazid were generated by...

Topics

Antitubercular Agents
Bacterial Proteins
Isoniazid
Manganese
Mutation
Mycobacterium tuberculosis
Oxidoreductases
Peroxidase
Peroxidases

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Identifiers

PMID: 12543676
DOI: 10.1128/AAC.47.2.670-675.2003
PMCID: PMC151726

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