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Article

Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.

Molecular microbiology - 1 Jan 1995

Heym B, Alzari P M, Honoré N, Cole S T

Abstract excerpt

The toxicity of the powerful anti-tuberculosis drug isoniazid (INH) is believed to be mediated by the haem-containing enzyme catalase-peroxidase, encoded by the katG gene of Mycobacterium tuberculosis. Compelling evidence for this was obtained by studying a panel of INH-resistant clinical isolates using a novel strategy based on the polymerase chain reaction and single-strand-conformation polymorphism analysis...

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Identifiers

PMID: 7746145
DOI: 10.1111/j.1365-2958.1995.tb02238.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.PMID 7746145Read ↗

Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis.Semantic proximity Read ↗

Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.Semantic proximity Read ↗

Mutation of katG in a clinical isolate of Mycobacterium tuberculosis: effects on catalase-peroxidase for isoniazid activation.Semantic proximity Read ↗

Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.Semantic proximity Read ↗

Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.Semantic proximity Read ↗

The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.Semantic proximity Read ↗

Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.Semantic proximity Read ↗

Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosisSemantic proximity Read ↗

Molecular Analysis of katG Encoding Catalase-Peroxidase from Clinical Isolate of Isoniazid-Resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Analysis of interactions of clinical mutants of catalase-peroxidase (KatG) responsible for isoniazid resistance in Mycobacterium tuberculosis with derivatives of isoniazid.Semantic proximity Read ↗

Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.Semantic proximity Read ↗

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