Article
Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.
Molecular microbiology - 1 Jan 1995
Heym B, Alzari P M, Honoré N, Cole S T
Abstract excerpt
The toxicity of the powerful anti-tuberculosis drug isoniazid (INH) is believed to be mediated by the haem-containing enzyme catalase-peroxidase, encoded by the katG gene of Mycobacterium tuberculosis. Compelling evidence for this was obtained by studying a panel of INH-resistant clinical isolate...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Catalase
- DNA Mutational Analysis
- DNA, Bacterial
- Drug Resistance, Microbial
- Genes, Bacterial
- Isoniazid
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Mycobacterium bovis
- Mycobacterium tuberculosis
- Oxidoreductases
- Peroxidases
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational