Article
Molecular analysis of isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates recovered from Barcelona.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2005
Coll Pere, Aragón Lina Marcela, Alcaide Fernando, Espasa Mateo, Garrigó Montserrat, González Julià, Manterola Jose M, Orús Pilar, Salvadó Margarita
Abstract excerpt
We studied the presence of mutations in the whole katG gene and specific regions of the oxyR-ahpC and mabA-inhA regulatory region in 61 Mycobacterium tuberculosis isoniazid-resistant isolates. An 81-bp region of the rpoB gene was also sequenced in 17 rifampin-resistant strains. Alterations in the katG gene were detected in 55% of the isolates. Mutation in codon 315 was the most prevalent (32%). Strains showed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.