Article
Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Huang Jianping, Khong Hung T, Dudley Mark E, El-Gamil Mona, Li Yong F, Rosenberg Steven A, Robbins Paul F
Abstract excerpt
Objective clinical responses have been observed in approximately 50% of patients who received non-myeloablative chemotherapy prior to the adoptive transfer of autologous melanoma-reactive tumor-infiltrating lymphocytes (TILs). Recent studies carried out through the use of antibodies directed against T-cell-receptor beta chain variable region (TRBV) products, as well as by direct sequencing of the expressed TRBV...
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